Understanding the preferential relationships between the cardinal pathologies
of Alzheimer?s disease and different aspects of the clinical phenotype 
   Lead Investigator:    Charles Malpas
   Institution      :    The University of Melbourne
   E-Mail           :    charles.malpas@unimelb.edu.au
   Proposal ID      :    998


   Publications:


1  Malpas CB, Sharmin S, Kalincik
   The histopathological staging of tau, but not amyloid, corresponds to antemortem cognitive status, dementia stage, functional abilities, and neuropsychiatric symptoms
   Journal Article  Int J Neurosci,epub ahead of print:doi: 10.1080/00,2020,PMC in process

   IN PRESS





   Proposal Description:
   The two cardinal pathologies of Alzheimer's disease (AD) develop according to distinct anatomical trajectories. Cerebral tau-related pathology first accumulates in the mesial temporal region, while amyloid-related pathology first appears in neocortex. The eventual distributions of these pathologies reflect their anatomical origins. An implication is that the cardinal pathologies might exert preferential effects on the brain networks and associated cognitive function. Our aim is to test this hypothesis using CSF, neuropathological, and neuropsychological data.